My primary role within CPIB was to develop mathematical models of hormone perception. This involved interacting closely with experimentalists (in particular Tara Holman, Benjamin Péret and Susana Úbeda-Tomás) to integrate their latest results into my models, and suggest novel experiments that validated my predictions. I also interacted with other mathematicians (Leah Band and Rosemary Dyson) to integrate my models into theirs, and with statisticians and computer scientists (Kim Kenobi, Claudio Lima and Jianyong Sun) to fit my models to the data generated in the lab. I also co-supervised PhD student Nathan Mellor (who is looking at Lax3 regulation) and summer student Fred Hoffman (who was looking at stochastic effects on the Aux/IAA negative feedback loop).
Alistair left CPIB in April 2010, and is currently working at the University of Heidelberg.
Published Work
- Middleton AM, Úbeda-Tomás S, Griffiths J, Holman T, Hedden P, Thomas SG, Phillips AL, Holdsworth MJ, Bennett MJ, King JR, Owen MR (2012) Mathematical modeling elucidates the role of transcriptional feedback in gibberellin signaling. In press in PNAS
Virtual Root
- L.R. Band, S. Ubeda-Tomas, R.J. Dyson, A.M. Middleton, T.C. Hodgman, M.R. Owen, O.E. Jensen, M.J. Bennett, J.R. King (2012) Growth-induced hormone dilution can explain the dynamics of plant root cell elongation. In press in PNAS
Virtual Root
- Leah R Band*, Darren M. Wells*, Antoine Larrieu*, Jianyong Sun*, Alistair M. Middleton*, Andrew P. French, Géraldine Brunoud, Ethel Mendocilla Sato, Michael H. Wilson, Benjamin Péret, Marina Oliva, Ranjan Swarup, Ilkka Sairanen, Geraint Parry, Karin Ljung, Tom Beeckman, Jonathan M. Garibaldi, Mark Estelle, Markus R. Owen, Kris Vissenberg, T. Charlie Hodgman, Tony P. Pridmore, John R King, Teva Vernoux, Malcolm J Bennett (2012) Root gravitropism is regulated by a transient lateral auxin gradient controlled by a tipping point mechanism. PNAS 109, 4668–4673 [* these authors contributed equally]
Virtual Root
- Middleton AM, King JR, Bennett MJ, Owen MR (2010) Mathematical modelling of the Aux/IAA negative feedback loop. Bulletin of Mathematical Biology 72, 1383–1407
Virtual Root
- Middleton A, King JR, Loose M (2009) Bistability in a model of mesoderm and anterior mesendoderm specification in Xenopus laevis. Journal of Theoretical Biology 260, 41–55