Darren Wells
background | publicationsMy main role is the characterisation of the engineering properties of plant materials at the sub-cellular, cellular and multi-cellular levels.
Projects within CPIB
Published Work
PAPERS
- Andrew P French, Michael H Wilson, Kim Kenobi, Daniela Dietrich, Ute Voss, Susana Ubeda-Tomas, Tony P Pridmore, Darren M Wells (2012) Identifying biological landmarks using a novel cell measuring image analysis tool: Cell-o-Tape. Accepted for publication in Plant Methods Virtual Root
- Géraldine Brunoud, Darren M. Wells*, Marina Oliva*, Antoine Larrieu*, Vincent Mirabet, Amy H. Burrow, Tom Beeckman, Stefan Kepinski, Jan Traas, Malcolm J. Bennett, Teva Vernoux (2012) A novel sensor to map auxin response and distribution at high spatio-temporal resolution. Nature 482, 103–106 [* these authors contributed equally]DOI: 10.1038/nature10791 Full-text @ Publishers websiteVirtual Root
- Leah R Band*, Darren M. Wells*, Antoine Larrieu*, Jianyong Sun*, Alistair M. Middleton*, Andrew P. French, Géraldine Brunoud, Ethel Mendocilla Sato, Michael H. Wilson, Benjamin Péret, Marina Oliva, Ranjan Swarup, Ilkka Sairanen, Geraint Parry, Karin Ljung, Tom Beeckman, Jonathan M. Garibaldi, Mark Estelle, Markus R. Owen, Kris Vissenberg, T. Charlie Hodgman, Tony P. Pridmore, John R King, Teva Vernoux, Malcolm J Bennett (2012) Root gravitropism is regulated by a transient lateral auxin gradient controlled by a tipping point mechanism. Accepted for publication in PNAS [* these authors contributed equally]Virtual Root
- Anwesha N Fernandes, Xinyong Chen, Colin A Scotchford , James Walker , Darren M Wells, Clive J Roberts, Nicola M Everitt (2012) Mechanical properties of epidermal cells of whole living roots of Arabidopsis thaliana: An atomic force microscopy study. In press in Physical Review E DOI: 10.1103/PhysRevE.85.021916 Full-text @ Publishers websiteVirtual Root
- Vernoux T, Brunoud G, Farcot E, Morin V, Van den Daele H, Legrand J, Oliva O, Das P, Larrieu A, Wells D, Guédon Y, Armitage L, Picard F, Guyomarc'h S, Cellier C, Parry G, Koumproglou R, Doonan JH, Kepinski S, Estelle M, Godin C, Bennett M, De Veylder L, Traas J (2011) The auxin signalling network translates dynamic input into robust patterning at the shoot apex. Molecular Systems Biology 7:508 DOI: 10.1038/msb.2011.39 Full-text @ Publishers websiteVirtual Root
- Naeem A, French AP, Wells DM, Pridmore TP (2011) High-throughput feature counting and measurement of roots. Bioinformatics 27, 1337–1338 Virtual Root
- Sethuraman VS, French AP, Wells DM, Kenobi K, Pridmore TP (2011) Tissue-Level Segmentation and Tracking of Cells in Growing Plant Roots. Machine Vision and Applications DOI: 10.1007/s00138-011-0329-9 Full-text @ Publishers websiteVirtual Root
- Wells DM, Wilson MH, Bennett MJ (2010) Feeling UPBEAT about Growth: Linking ROS Gradients and Cell Proliferation. Developmental Cell 19, 644–6 Virtual Root
- Qian M, Wells DM, Jones A, Becker A (2010) Finite element modelling of cell wall properties for onion epidermis using a fibre-reinforced hyperelastic model. Journal of Structural Biology 172, 300–4 Virtual Root
- Wright EF, Wells DM, French AP, Howells C, Everitt NM (2009) A low-cost automated focusing system for time-lapse microscopy. Measurement Science & Technology 20 DOI: 10.1088/0957-0233/20/2/027003 Full-text @ Publishers websiteVirtual Root
- Miller AJ, Fan X, Smith SJ, Wells DM (2007) Nitrate transport and signalling. Journal of Experimental Botany 58, 2297–2306 DOI: 10.1093/jxb/erm066 Full-text @ Publishers website
- Clark LJ, Gowing DJG, Lark RM, Leeds-Harrison PB, Miller AJ, Wells DM, Whalley WR, Whitmore AP (2005) Sensing the physical and nutritional status of the root environment in the field: a review of progress and opportunities. Journal of Agricultural Science 143, 347–358 DOI: 10.1017/S0021859605005253 Full-text @ Publishers website
REPORTS
- Middleton AM, Dyson RJ, Band LR, Grandison S, Wells DM, Holman TJ, Twycross J, Jensen OE (2008) The Mechanics of Arabidopsis Seed Germination. Proceedings of the Mathematics in the Plant Sciences Study Group Virtual Root
- Wells DM, Miller AJ (2005) Soil sensors for nitrogen availability. DEFRA Final Report
BOOKS or CHAPTERS
- Andrew French, Darren Wells, Nicola Everitt, Tony Pridmore (2012) High-Throughput Quantification of Root Growth. Measuring Roots: An Updated Approach. Chapter 7. Mancuso, Stefano (Ed.) January 1, 2012 ISBN: ISBN 978-3-642-22066-1Virtual Root
- Michael Burrell, Simona Francese, Duncan D. Cameron, Chloe Steels, Malcolm Bennett, Darren Wells, Tara Holman, Jonathan Leake, Malcolm Clench (2010) MALDI-MSI – a new tool for metabolite analysis in forensic science. ISBN: 978-989-26-0049-9Virtual Root
- Miller AJ, Borras J, Smith SJ, Wells DM (2007) Measuring changes in soil nutrient availability at the root surface using ion-selective electrodes in Advanced Technologies for Measuring Nutrient and Water Availability to Plants. Proceedings of the Dahlia Greidinger Symposium, Grand Water Research Institute, Haifa pp. 31-49
- Miller AJ, Wells DM (2006) Electrochemical methods and measuring trans-membrane ion gradients. Plant Electrophysiology – Theory and Methods. Volkov, A.J. (Ed.) Springer-Verlag pp 15-34 ISBN: 978-3-540-32717-2
CONFERENCE-PROCEEDINGS
- Sethuraman V, Taylor S, Pridmore TP, French AP, Wells DM (2009) Segmentation and Tracking of Confocal Images of Arabidopsis thaliana Root Cells using Automatically-Initialized Network Snakes. 3rd International Conference on Bioinformatics and Biomedical Engineering, Beijing, ChinaVirtual Root
Presented Work
PRESENTATIONS
- Virtual Plants. At: Knowledge Transfer Seminar, University of Nottingham June 22nd 2011 Darren WellsVirtual Root
- Auxin redistribution during gravitropism: new insights from a novel reporter and a systems-biology approach. At: Plant and Crop Sciences Seminar, University of Nottingham June 8th 2011 Leah Band, Darren WellsVirtual Root
- Systems Analysis of Root Cell Expansion. At: Modelling Cell Elongation Workshop. University of Nottingham February 7th-8th 2011 Darren Wells, Ester CanchoVirtual Root
- Systems Analysis of Hormone regulated Root Gravitropism: new insights into an old question.... At: 5th Annual BBSRC Grant Holders meeting, Imperial College London 2011 Bennett MJ, Wells DM, Band LRVirtual Root
- Seed traits and plant coexistence: Capsella as a model. At: British Ecological Society 2010 Annual Meeting 2010 IANNETTA PPM, BEGG GS, KARLEY A, VALENTINE T, HOLMAN T, WELLS D, DENG W, JENG DS, SQUIRE G, TOOROP, PVirtual Root
- Gravitropism. At: CPIB Showcase, University of Nottingham September 1st-2nd 2010 Darren Wells, Leah BandVirtual Root
- Cryo FIB/SEM of plant material. At: Nottingham Nanotechnology and Nanoscience Centre Researchers Forum. University of Nottingham July 26th 2010 Darren WellsVirtual Root
- Auxin redistribution during root gravitropism: a systems biology approach. At: Plant Systems Biology Workshop, University of Nottingham, UK 1st-3rd June 2010 Band L, Sun J, Larrieu A, Wells DVirtual Root
- Segmentation and tracking of networks of Arabidopsis thaliana cells through Confocal laser microscope images. At: Microscopy Image Analysis for Biomedical Applications: A One Day BMVA symposium at the British Computer Society, London, UK 2010 V Sethuraman, A French, D Wells, T PridmoreVirtual Root
- Imaging auxin responses and cell expansion in real time. At: USPA Workshop. University of Nottingham October 12th-13th 2009 DM Wells, T Holman, AP FrenchVirtual Root
- Seed life history traits and myxospermy in time-to-flowering variants of shepherd’s purse (Capsella bursa-pastoris (L.) Medic.). At: British Ecological Society Annual Meeting - University of Hertfordshire 2009 Iannetta PPM, Valentine T, Holman TJ, Wells DM, Begg GS, Wishart J, Toorop PEVirtual Root
- Interdisciplinary Minisymposium: Plant root cell expansion. At: Society for Mathematical Biology Annual Meeting - University of British Columbia, CA Invited speaker at 2009 Wells DMVirtual Root
- Dissecting root cell expansion: from genes to jam. At: CPIB presentation to Syngenta - Syngenta, Jealotts Hill, UK 2009 Holman TJ, Dyson RJ, Wells DMVirtual Root
- Dissecting root cell expansion. At: Biomechanics of Growth in Plant Biology Event - University of Bristol 2009 Wells DMVirtual Root
- Of shape and function: a case study of lateral root primordia in Arabidopsis thaliana. At: UK Plant Systems Biology Meeting - Warwick-HRI, UK 2009 Lucas M, Evans K, Wells DM, French AP, Bennett MJVirtual Root
- CPIB: Modelling plant cell wall mechanics: from genes to jam. At: BBSRC Systems Biology Grantholder Workshop - University of Nottingham, UK 2008 Bennett MJ, Holman TJ, Dyson RJ, Wells DMVirtual Root
- FIB and CryoFIB as applied to the life Sciences. At: 4th European FIB and Dual Beam User Club Meeting - Edinburgh, UK 2008 Edwards HK, Fay MW, Wells DM, Holman TJ, Coe S, Marriot T, Ahmed I, Anderson SI, Brown PDVirtual Root
POSTERS
- Using engineering techniques to investigate plant biology questions. At: Annual Plant Biology Symposium at the University of Massachusetts Amherst 2011 Nicola Everitt, Darren Wells, Andy FrenchVirtual RootvSeed
- DRIVE-db. At: 5th BBSRC Systems Biology Grant Holders' Workshop 2011 Michael Wilson, Andrew French, Darren Wells, Michael Stout, Charlie Hodgman, Tony PridmoreVirtual Root
- Segmentation and Tracking of Networks of Arabidopsis thaliana Cells through Confocal Laser Microscope Images. At: 11th International Conference on Systems Biology, Edinburgh, Scotland, UK 2010 Andrew French, Vijay Sethuraman, Darren Wells, Tony PridmoreVirtual Root
- The mechanics of cell expansion in the root elongation zone. At: Modelling at multiple scales in biology, Oxford 2010 RJ Dyson, T Holman, DM Wells, M Wilson, MJ Bennett, NM Everitt, OE Jensen Virtual Root
- Segmentation and tracking of Arabidopsis thaliana root cells using automatically initialized network snakes. At: 4th BBSRC Systems Biology Grant Holders' Workshop. Edinburgh 2010 V Sethuraman, AP French, DM Wells, J Twycross, TP PridmoreVirtual Root
- Characterising the mechanical properties of elongating root cells. At: 20th International Conference on Arabidopsis Research - Edinburgh, UK 2009 Wells DM, Dyson RJ, Qian M, Bennett MJ, Hodgman TC, Jensen OE, Everitt NMVirtual Root
- High-throughput functional genomics of cell wall dynamics during root growth and development. At: 20th International Conference on Arabidopsis Research - Edinburgh, UK 2009 Holman TJ, Wilson MH, Wells DM, Sørensen I, Willats W, Knox JP, Holdsworth MJ, Bennett MJVirtual Root
- The CPIB RootAtlas: A Tool For Viewing Integrative Root Systems Biology Data. At: 20th International Conference on Arabidopsis Research - Edinburgh, UK 2009 Wilson MH, Holman TJ, French AP, Stout M, Wells DM, Kenobi K, Bennett MJ, Holdsworth MJ, Pridmore TP, Hodgman TCVirtual Root
- High throughput quantification of root growth. At: 20th International Conference for Arabidopsis Research. Edinburgh 2009 Andrew French, Darren M. Wells, Susana Ubeda-Tomás, Tara J. Holman, Nicola M. Everitt, Malcolm J. Bennett, Tony PridmoreVirtual Root
- High-throughput functional genomics of cell wall dynamics during root growth and development. At: UK Plant Systems Biology Meeting - Warwick-HRI, UK 2009 Holman TJ, Wilson MH, Wells DM, Sørensen I, Willats W, Knox JP, Holdsworth MJ, Bennett MJVirtual Root
- A fibre-reinforced fluid model of anisotropic plant cell growth. At: BBSRC Systems Biology Grantholder Workshop - University of Nottingham, UK 2008 Dyson RJ, Wells DM, Qian M, Becker A, Everitt NM, Jensen OE, King JR, Jones A, Tansley GVirtual Root
- A fibre-reinforced fluid model of anisotropic plant cell growth. At: MMBNOTT/MRM Summer Workshop in Mathematical Medicine and Biology - University of Nottingham, UK 2008 Dyson RJ, Wells DM, Qian M, Becker A, Everitt NM, Jensen OE, King JR, Jones A, Tansley GVirtual Root
- Systems biology approaches to root growth: visualisation and mathematical modelling. At: Third Conference on the Biosynthesis of Plant Cell Walls - Asilomar, CA 2008 Wells DM, Dyson RJ, Qian M, Wilson MH, Bennett MJ, Everitt NM, Jensen OE, Jones A, Tansley GDVirtual Root