Mike Holdsworth is Professor of Crop Science and Director of Crop Sciences at the University of Nottingham. He is the Manager of Strand 1 of the CPIB virtual root project and Project Leader for the vSEED project.
- Current research programmes, recent publications etc are available on the Portal for the laboratory of Professor Holdsworth
- The University web page of Professor Michael Holdsworth
- The web page for the ERANET-PG funded vSEED consortium
Research programmes focus on:
- Understanding the control of seed germination and seedling establishment.
- The function of the hormone Abscisic Acid (ABA), and plant responses to abiotic stress.
- Systems approaches, integrating genetics, post-genomics, physiology, mathematics, computer science and engineering, are being used to understand and manipulate plant development and environmental responses.
- Emphasis is placed on the transfer of molecular genetic information from studies in model species such as Arabidopsis and rice, to address important agricultural problems associated with plant developmental biology and response to abiotic stress.
Published Work
- Middleton AM, Úbeda-Tomás S, Griffiths J, Holman T, Hedden P, Thomas SG, Phillips AL, Holdsworth MJ, Bennett MJ, King JR, Owen MR (2012) Mathematical modeling elucidates the role of transcriptional feedback in gibberellin signaling. In press in PNAS
Virtual Root
- Gibbs DJ, Lee SC, Isa NM, Gramuglia S, Fukao, T, Bassel GW, Sousa Correia C, Corbineau F, Theodoulou FL, Bailey-Serres J, Holdsworth MJ (2011) Homeostatic response to hypoxia is regulated by the N-end rule pathway in plants. Nature 479, 415–418
vSeed
- Pearce S.P., King J.R., Holdsworth M.J. (2011) Axisymmetric indentation of curved elastic membranes by a convex rigid indenter. International Journal of Non-Linear Mechanics 46(9), 1128–1138
vSeed
- Bassel GW, Glaab E, Marquez J, Holdsworth MJ, Bacardit J (2011) Functional Network Construction in Arabidopsis Using Rule-Based Machine Learning on Large-Scale Data Sets. The Plant Cell 23, 3101–3116
vSeed
- Dupeux F, Santiago J, Betz K, Twycross J, Park S-Y, Rodriguez L, Gonzalez-Guzman M, Jensen M, Krasnogor N, Holdsworth MJ, Blackledge M, Cutler S, Rodriguez P, Marquez J (2011) A Thermodynamic Switch Modulates Abscisic Acid Receptor Sensitivity. EMBO Journal 30, 4171 – 4184
vSeed
- Bassel G, Holdsworth M, Provart N (2011) Seed bioinformatics. Methods in Molecular Biology 773 (8), 403–419
vSeed
- Bassel G.W., Lan H., Gibbs D.J., Gerjets T., Krasnogor N., Bonner A.J., Holdsworth M.J., Provart N.J. (2011) Genome-wide network model capturing seed germination reveals coordinated regulation of plant cellular phase transitions. Proceedings of the National Academy of Sciences of the United States of America 108, 9709–14
vSeed
- Lucas M, Swarup R, Paponov IA, Swarup K, Casimiro I, Lake D, Péret B, Zappala S, Mairhofer S, Whitworth M, Wang J, Ljung K, Marchant A, Sandberg G, Holdsworth MJ, Palme K, Pridmore T, Mooney S, Bennett MJ (2010) Short-Root regulates primary, lateral, and adventitious root development in Arabidopsis. Plant Physiology 155, 384–98
Virtual Root
- Holman TJ*, Wilson MH*, Kenobi K*, Dryden IL, Hodgman TC, Wood ATA, Holdsworth MJ (2010) Statistical evaluation of transcriptomic data generated using the Affymetrix one-cycle, two-cycle and IVT-Express RNA labelling protocols with the Arabidopsis ATH1 microarray. Plant Methods 6, 9 [*authors contributed equally.]
Virtual Root
- Holman TJ, Jones PD, Russell L, Medhurst A, Úbeda-Tomás S, Talloji P, Footitt S, Bachmair A, Theodoulou FL, Holdsworth MJ (2009) The N-end rule pathway promotes seed germination and establishment through removal of ABA sensitivity in Arabidopsis. PNAS 106, 4549–4554
vSeed
- Dietrich D, Schmuths H, DeMarcos Lousa C, Baldwin JM, Baldwin SA, Baker A, Theodoulou FL, Holdsworth M (2009) Mutations in the Arabidopsis ABC Transporter COMATOSE allow differentiation between different functions in planta: insights from an allelic series. Molecular Biology of the Cell 20, 530–543
vSeed
- Holdsworth MJ, Finch-Savage WE, Grappin P, Job D (2008) Post-genomics dissection of seed dormancy and germination. Trends In Plant Science 13, 7–13
- Carrera E, Holman TJ, Medhurst A, Dietrich D, Footitt S, Theodoulou FL, Holdsworth MJ (2008) Seed after-ripening is a discrete developmental pathway associated with specific gene networks in Arabidopsis. The Plant Journal 53, 214–224
- Footitt S, Dietrich D, Fait A, Fernie AR, Holdsworth MJ, Baker A, Theodoulou FL (2007) The COMATOSE ATP-binding cassette transporter is required for full fertility in Arabidopsis. Plant Physiology 144, 1467–1480
- Holdsworth MJ, Bentsink L, Soppe WJJ (2007) Molecular networks regulating Arabidopsis seed maturation, after-ripening, dormancy and germination. New Phytologist 179, 33–54
Presented Work
- High-throughput functional genomics of cell wall dynamics during root growth and development. At: 20th International Conference on Arabidopsis Research - Edinburgh, UK 2009 Holman TJ, Wilson MH, Wells DM, Sørensen I, Willats W, Knox JP, Holdsworth MJ, Bennett MJ
Virtual Root
- Regulation of ABA signalling and lipid catabolism by the N-end rule pathway of targeted protein degradation. At: 20th International Conference on Arabidopsis Research - Edinburgh, UK 2009 Holman TJ, Jones PD, Russell L, Medhurst A, Úbeda-Tomás S, Talloji P, Footitt S, Bachmair A, Theodoulou FL, Holdsworth MJ
Virtual Root
- The CPIB RootAtlas: A Tool For Viewing Integrative Root Systems Biology Data. At: 20th International Conference on Arabidopsis Research - Edinburgh, UK 2009 Wilson MH, Holman TJ, French AP, Stout M, Wells DM, Kenobi K, Bennett MJ, Holdsworth MJ, Pridmore TP, Hodgman TC
Virtual Root
- High-throughput functional genomics of cell wall dynamics during root growth and development. At: UK Plant Systems Biology Meeting - Warwick-HRI, UK 2009 Holman TJ, Wilson MH, Wells DM, Sørensen I, Willats W, Knox JP, Holdsworth MJ, Bennett MJ
Virtual Root
- A transcriptomic approach to investigate the effect of gibberellins on the elongation of Arabidopsis roots. At: GARNet-SEB Symposium - University of Nottingham, UK 2008 Holman TJ, Wilson MH, Úbeda-Tomás S, Griffiths J, Hedden P, Phillips A, Thomas S, Holdsworth MJ, Bennett MJ
Virtual Root
- A transcriptomic approach to investigate the effect of gibberellins on the elongation of Arabidopsis roots. At: Centre for Biochemistry and Cell Biology 3rd Annual Symposium - University of Nottingham, UK 2007 Holman TJ, Wilson MH, Úbeda-Tomás S, Griffiths J, Hedden P, Phillips A, Thomas S, Holdsworth MJ, Bennett MJ
Virtual Root
- A transcriptomic approach to investigate the effect of gibberellins on the elongation of Arabidopsis roots. At: BBSRC Systems Biology Grantholder Workshop - Newcastle, UK 2007 Holman TJ, Wilson MH, Úbeda-Tomás S, Griffiths J, Hedden P, Phillips A, Thomas S, Holdsworth MJ, Bennett MJ
Virtual Root