Receptor-Like Kinase ACR4 Restricts Formative Cell Divisions in the Arabidopsis Root

Ive De Smet, Valya Vassileva, Bert De Rybel, Mitchell P. Levesque, Wim Grunewald, Daniël Van Damme, Giel Van Noorden, Mirande Naudts, Gert Van Isterdael, Rebecca De Clercq, Jean Y. Wang, Nicholas Meuli, Steffen Vanneste, Jiří Friml, Pierre Hilson, Gerd Jürgens, Gwyneth C. Ingram, Dirk Inzé, Philip N. Benfey & Tom Beeckman

During the development of multicellular organisms, organogenesis and pattern formation depend on formative divisions to specify and maintain pools of stem cells. In higher plants, these activities are essential to shape the final root architecture because the functioning of root apical meristems and the de novo formation of lateral roots entirely rely on it. We used transcript profiling on sorted pericycle cells undergoing lateral root initiation to identify the receptor-like kinase ACR4 of Arabidopsis as a key factor both in promoting formative cell divisions in the pericycle and in constraining the number of these divisions once organogenesis has been started. In the root tip meristem, ACR4 shows a similar action by controlling cell proliferation activity in the columella cell lineage. Thus, ACR4 function reveals a common mechanism of formative cell division control in the main root tip meristem and during lateral root initiation.

Science 322 (5901), 594-597

Read the Full Text at the publishers site
(may require institutional login)