Intracellular posttranslational protein targeting
Protein localisation underpins cellular architecture and biochemical networks. Whilst we understand the steady state condition and many of the protein targeting processes, we lack a global model of protein segregation. In the simplest model, proteins possess a signal sequence that is bound by a targeting factor, which ensures delivery to a specific organelle. Although this may be specific and robust in some cases, it is possible for proteins to become mistargeted in a wide range of conditions. Furthermore, some proteins are targeted to multiple locations to facilitate their normal functions. Our hypothesis is that proteins are segregated by competitive binding of targeting factors, and by specific recognition at organellar receptors. The aim of this proposal is to devise a systematic framework for understanding how protein segregation occurs reliably and flexibly.
Proceedings of the 3rd Mathematics in the Plant Sciences study group