The tetrapyrrole biosynthesis pathway in higher plants as an example of a subcellular network

Alison Smith & Michael Moulin

Three specific questions that might provide a framework for a mathematical model are:
i. do the data we have on the gene expression and levels of intermediates account for
the time course of chlorophyll synthesis on illumination of dark-grown seedlings?
ii. which intermediates correlate best with inhibition of expression of apoprotein genes?
iii. can the haem feed-back model account for the levels of intermediates seen in mutants of the pathway?

Proceedings of the Mathematics in the Plant Sciences Study Group